An overview of recent treatment options for primary sclerosing cholangitis

Ioanna Mousavere; Georgios Kalampokis; Fotios Fousekis; Peter Karayiannis; Gerasimos Baltayiannis; Dimitrios Christodoulou

Authors Ioanna Mousavere, Georgios Kalampokis, Fotios Fousekis, Peter Karayiannis, Gerasimos Baltayiannis, Dimitrios Christodoulou.

Abstract

Primary sclerosing cholangitis (PSC) is a chronic hepatic dysfunction characterized by inflammatory and tissue-degenerative strictures of the biliary tree, leading to cirrhosis and cholangiocarcinoma. The pathophysiological mechanisms involve immune-mediated responses. Numerous treatment modalities targeting the inflammatory aspects have been suggested, but a consensus on the best treatment option is lacking. This study aims to review the most up-to-date treatment options for PSC.

Keywords Primary sclerosing cholangitis, treatment, management

Ann Gastroenterol 2023; 36 (6,): 589-598