A comparative study of combination octreotide plus methylprednisolone with octreotide and placebo on prevention of post-endoscopic retrograde cholangiopancreatography (ERCP)pancreatitis

Authors . Katsinelos P., . Christodoulou K., Pilpilidis I., Xiarchos P., Vasiliadis Th., Katsiba D., Kalomenopoulou M., Joseph Ch..


This study compares the effect of the combination of octreotide
plus methylprednisolone with octreotide and placebo
on biochemical and clinical parameters of endoscopic retrograde
cholangiopancreatograpy (ERCP) induced pancreatitis.
Two hundred and twenty two patients were randomised
to receive either octreotide plus methylprednisolone,
octreotide or placebo. There was no difference in the
median serum amylase at 2 to 24 hours after ERCP in the
three groups. Clinical pancreatitis, developed in 11 patients
-one in the octretode plus methylprednisolone, four in the
octretode and six in the placebo groups, although there was
no statistically significant difference between the three
groups. This study suggests a tendency that octreotide plus
methylprednisolone may protect against ERCP- induced
Key words: Octreotide, Methylprednisolone, Hyperamylasemia,
Pancreatitis, Endoscopic Retrograde Cholangiopancreatography.
Abbreviations: Endoscopic Retrograde Cholangiopancreatography
(ERCP), Endoscopic Sphincterotomy (ES)
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