Early effect on intragastric pH of oral administration of rabeprazole with mosapride compared with rabeprazole alone

Authors Hiroshi Iida, Megumi Kaai, Yumi Inoh, Kenji Kanoshima, Kanji Ohkuma, Takashi Nonaka, Koji Fujita, Tomonori Ida, Akihiko Kusakabe, Shin Maeda, Atsushi Nakajima, Masahiko Inamori.


Background An ideal medication for acid-related diseases would offer prompt stopping of blood flow as well as efficient symptom resolution. The aim of this study was to investigate the gastric acid suppression potency of a single oral dose of rabeprazole alone, compared with administration of rabeprazole plus mosapride.

Methods Twelve male volunteers, Helicobacter pylori (H. pylori)-negative, participated in this randomized, three-way crossover study. After a single oral administration of rabeprazole, rabeprazole with mosapride, or rabeprazole administered 1 h after mosapride, we monitored their intragastric pH constantly for 6 h. A 7-day washout period was allowed between each administration.

Results The median 6-h intragastric pH after the administration of rabeprazole 1 h after mosapride was 4.41±1.22 (mean±s.d.), significantly higher than after rabeprazole alone 3.45±1.33, P=0.0376). There was no significant difference between the median 6-h pH after the administration of rabeprazole plus mosapride and that after rabeprazole alone (3.81±0.98 vs. 3.45±1.33, respectively; P=0.0927).

Conclusion An oral dose of rabeprazole administered 1 h after mosapride increased the intragastric pH more rapidly than rabeprazole alone, in healthy, male, H. pylori-negative volunteers.

Keywords Intragastric acidity, rabeprazole, mosapride

Ann Gastroenterol 2017; 30 (4): 424-428

Original Articles