Systemic lupus erythematosus in Crohn's disease: drug-induced or idiopathic?

Authors George Michalopoulos, Spyridon Vrakas, Konstantinos Makris, Charalampos Tzathas.


Coexistence of Crohn's disease (CD) and idiopathic systemic lupus erythematosus (SLE) is very rare. On the other hand, drug-induced lupus erythematosus (DILE) due to anti-tumor necrosis factor (TNF) agents is a relatively more common entity. DILE due to anti-TNF agents and idiopathic SLE share common serologic and epidemiologic characteristics making the differentiation between those two entities difficult. We present a case of a 35-year-old woman with CD who developed SLE after treatment with adalimumab and denosumab and persisting symptoms eight months after discontinuation of those agents.

Keywords Crohn's disease, SLE, DILE, adalimumab, denosumab

Ann Gastroenterol 2015; 28 (3): 406-407

Case Reports