Helicobacter pylori infection in patients with active pulmonary tuberculosis before the initiation of antituberculosis treatment

Authors N. Philippou, A. Roussos, F. Tsimpoukas, Evgenia Anastasakou,, Stavroula Mavrea, Angeliki Tsimogianni ..


Objectives: A high Helicobacter pylori (H. pylori) seroprevalence
has been found in many extragastrointestinal disorders.
Moreover, it has been reported that the tuberculosis
(TB) risk may be increased in patients with a history of
peptic ulcer disease. The aim of this study was to assess
the H. pylori seroprevalence in patients with newly diagnosed
pulmonary TB, before the initiation of antituberculosis
Methods: We evaluated all patients with newly diagnosed
pulmonary TB presenting to our hospital during a 2-year
period. We evaluated 80 patients with pulmonary TB and
70, age and sexmatched, control subjects. All enrolled subjects
(tuberculosis patients and controls) underwent an
enzyme-linked immunosorbent assay (ELISA) IgG serologic
test for H. pylori diagnosis.
Results: A correlation between age and H. pylori IgG level
was detected for both TB patients (r=0.42, p=0.004) and
controls (r=0.44, p=0.004). The H. pylori seropositivity in
the TB group was significantly higher than that of controls
(87.5% vs 61.4%, p=0.02). The mean serum concentration
of IgG antibodies against H. pylori was also significantly
higher in TB patients than in control subjects (39.0± 25.2
U/ml vs 26.1±21.2 U/ml, p=0.001).
Conclusions: H. pylori infection may be associated with pulmonary TB. Further studies should be undertaken to confirm
our results and to clarify the potential underlying
pathogenetic mechanisms.
Key words: Helicobacter Pylori, Prevalence, Tuberculosis
Original Articles