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Cholestatic hepatitis associated with amoxycillin – clavulanic acicombination. A case reportd
Abstract
SUMMARY
Several cases have been reported with amoxycillin – clavulanic
acid induced hepatic illness. Most of them had cholestatic
hepatitis but there were also cases with hepatocellular
or mixed type. We report a case of cholestatic hepatitis
in a 73-year-old woman with sinusitis who took this drug
combination for 12-days and developed cholestatic hepatitis
about 60 days later. This case is unusual because the
patient was a woman with no other health problems and
there was a long period before the onset of the symptoms.
We also make a review in the literature.
Key words: Cholestatic hepatitis, Augmentin, Amoxicillin,
pharmaceutical jaundice.
Several cases have been reported with amoxycillin – clavulanic
acid induced hepatic illness. Most of them had cholestatic
hepatitis but there were also cases with hepatocellular
or mixed type. We report a case of cholestatic hepatitis
in a 73-year-old woman with sinusitis who took this drug
combination for 12-days and developed cholestatic hepatitis
about 60 days later. This case is unusual because the
patient was a woman with no other health problems and
there was a long period before the onset of the symptoms.
We also make a review in the literature.
Key words: Cholestatic hepatitis, Augmentin, Amoxicillin,
pharmaceutical jaundice.